BAM 7
BAM 7 is a Bax activator (EC50 = 3.3 μM). BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell survival. The antiapoptotic BH3-binding groove has been successfully targeted to reactivate apoptosis in cancer.
1: Gavathiotis E, Reyna DE, Bellairs JA, Leshchiner ES, Walensky LD. Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 Jul;8(7):639-45. doi: 10.1038/nchembio.995. Epub 2012 May 27. PubMed PMID: 22634637; PubMed Central PMCID: PMC3617124.
| Chemical | |
|---|---|
| CAS Num | 331244-89-4 |
| Chemical Formula | C21H19N5O2S |
| Molecular Weight | 405.476 |
| IUPAC Chemical Name | (E)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one |
| Exact Mass | 405.1259 |
| Elemental Analysis | C, 62.21; H, 4.72; N, 17.27; O, 7.89; S, 7.91 |
| Synonym | BAM 7; BAM-7; BAM7. |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C)C3=N\NC4=CC=CC=C4OCC |
| Biological | |
| Targets and Effects | N/A |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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