Baicalin
Baicalin is a flavone, a type of flavonoid. It is found in several species in the genus Scutellaria, including Scutellaria lateriflora (blue skullcap). There are 10 mg/g baicalin in Scutellaria galericulata (common skullcap) leaves. Baicalin is the glucuronide of baicalein. It is a component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis) and one of the chemical ingredients of Sho-Saiko-To, an herbal supplement. Baicalin is a known prolyl endopeptidase inhibitor, induces apoptosis in pancreatic cancer cells, and affects the GABA receptors.
1: Chai YS, Lei F, Xing DM, Ding Y, Du LJ. [Effect of baicalin on pattern recognition receptor TLR2/4-NOD2 and its significance of druggability]. Zhongguo Zhong Yao Za Zhi. 2013 Aug;38(16):2639-44. Review. Chinese. PubMed PMID: 24228579.
2: Sahebkar A. Baicalin as a potentially promising drug for the management of sulfur mustard induced cutaneous complications: a review of molecular mechanisms. Cutan Ocul Toxicol. 2012 Sep;31(3):226-34. doi: 10.3109/15569527.2011.633950. Epub 2011 Nov 22. Review. PubMed PMID: 22107027.
3: Srinivas NR. Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives. Xenobiotica. 2010 May;40(5):357-67. doi: 10.3109/00498251003663724. Review. PubMed PMID: 20230189.
4: Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 2009 Feb;35(1):57-68. doi: 10.1016/j.ctrv.2008.09.005. Epub 2008 Nov 11. Review. PubMed PMID: 19004559.
5: Zhu Y. [The study on baicalin in China]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Sep;13(9):567-9. Review. Chinese. PubMed PMID: 8111218.
2: Sahebkar A. Baicalin as a potentially promising drug for the management of sulfur mustard induced cutaneous complications: a review of molecular mechanisms. Cutan Ocul Toxicol. 2012 Sep;31(3):226-34. doi: 10.3109/15569527.2011.633950. Epub 2011 Nov 22. Review. PubMed PMID: 22107027.
3: Srinivas NR. Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives. Xenobiotica. 2010 May;40(5):357-67. doi: 10.3109/00498251003663724. Review. PubMed PMID: 20230189.
4: Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 2009 Feb;35(1):57-68. doi: 10.1016/j.ctrv.2008.09.005. Epub 2008 Nov 11. Review. PubMed PMID: 19004559.
5: Zhu Y. [The study on baicalin in China]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Sep;13(9):567-9. Review. Chinese. PubMed PMID: 8111218.
| Chemical | |
|---|---|
| CAS Num | 21967-41-9 |
| Chemical Formula | C21H18O11 |
| Molecular Weight | 446.36 |
| IUPAC Chemical Name | (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid |
| Exact Mass | 446.08491 |
| Elemental Analysis | C, 56.51; H, 4.06; O, 39.43p |
| Solubility | Soluble in DMSO. |
| SMILES Code | O=C([C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC3=C(C(O)=C2O)C(C=C(C4=CC=CC=C4)O3)=O)O1)O |
| Biological | |
| Targets and Effects | gamma-amino butyric acid (GABA) |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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