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Anba Pharma BDA-366 CAS No.: 1821496-27-8 .. Product #: Anba-003559 Regular price: $233.00 $233.00


Catalog No.: Anba-003559
Weight: 10mg

Price: $233.00

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BDA-366 is a BCL2-BH4 antagonist. BDA-366 suppresses human myeloma growth. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without significant cytotoxic effects on normal hematopoietic cells or body weight. Thus, BDA-366 functions as a novel BH4-based BCL2 inhibitor and offers an entirely new tool for MM therapy.

1: Deng J, Park D, Wang M, Nooka A, Deng Q, Matulis S, Kaufman J, Lonial S, Boise LH, Galipeau J, Deng X. BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth. Oncotarget. 2016 May 10;7(19):27753-63. doi: 10.18632/oncotarget.8513. PubMed PMID: 27049723; PubMed Central PMCID: PMC5053685.
2: Han B, Park D, Li R, Xie M, Owonikoko TK, Zhang G, Sica GL, Ding C, Zhou J, Magis AT, Chen ZG, Shin DM, Ramalingam SS, Khuri FR, Curran WJ, Deng X. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 2015 Jun 8;27(6):852-63. doi: 10.1016/j.ccell.2015.04.010. PubMed PMID: 26004684; PubMed Central PMCID: PMC4470473.
3: Vervloessem T, La Rovere R, Bultynck G. Antagonizing Bcl-2's BH4 domain in cancer. Aging (Albany NY). 2015 Oct;7(10):748-9. PubMed PMID: 26525307; PubMed Central PMCID: PMC4637201.
4: Liu Z, Wild C, Ding Y, Ye N, Chen H, Wold EA, Zhou J. BH4 domain of Bcl-2 as a novel target for cancer therapy. Drug Discov Today. 2016 Jun;21(6):989-96. doi: 10.1016/j.drudis.2015.11.008. Review. PubMed PMID: 26631752; PubMed Central PMCID: PMC4882289.
5: Selective Inhibition of BCL2 Shows Antitumor Effects in Lung Cancer. Cancer Discov. 2015 Jul;5(7):OF21. doi: 10.1158/2159-8290.CD-RW2015-102. PubMed PMID: 26045015.
CAS Num 1821496-27-8
Chemical Formula C24H29N3O4
Molecular Weight 423.513
IUPAC Chemical Name 1-(((S)-3-(diethylamino)-2-hydroxypropyl)amino)-4-((((S)-oxiran-2-yl)methyl)amino)anthracene-9,10-dione
Exact Mass 423.2158
Elemental Analysis C, 68.06; H, 6.90; N, 9.92; O, 15.11
Synonym BDA-366; BDA 366; BDA366.
Solubility Soluble in DMSO
Targets and Effects N/A
Pathways Apoptosis
Appearance Solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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Anba Pharma Company
3-H Gill Street, Suite 300
Woburn, MA 01801
United State

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Tel: 1+610-883-0668


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