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Anba Pharma AdipoRon CAS No.: 924416-43-3 .. Product #: Anba-002717 Regular price: $102.00 $102.00


Catalog No.: Anba-002717
Weight: 10mg

Price: $102.00

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AdipoRon is a potent and selective adiponectin receptor agonist. AdipoRon attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon may be a promising therapeutic approach for the treatment of obesity-related disease.

1: Malih S, Najafi R. AdipoRon: a possible drug for colorectal cancer prevention? Tumour Biol. 2015 Aug 18. [Epub ahead of print] PubMed PMID: 26282004.   2: Zhang Y, Zhao J, Li R, Lau WB, Yuan YX, Liang B, Li R, Gao EH, Koch WJ, Ma XL, Wang YJ. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82. doi: 10.1152/ajpendo.00577.2014. Epub 2015 Jun 2. PubMed PMID:  26037251; PubMed Central PMCID: PMC4525114.   3: Dib J, Schlörer N, Schänzer W, Thevis M. Studies on the collision-induced dissociation of adipoR agonists after electrospray ionization and their implementation in sports drug testing. J Mass Spectrom. 2015 Feb;50(2):407-17. doi: 10.1002/jms.3545. PubMed PMID: 25800023.   4: Lee S, Kwak HB. Role of adiponectin in metabolic and cardiovascular disease. J Exerc Rehabil. 2014 Apr 30;10(2):54-9. doi: 10.12965/jer.140100. eCollection 2014 Apr. Review. PubMed PMID: 24877038; PubMed Central PMCID: PMC4025550.   5: Holland WL, Scherer PE. Cell Biology. Ronning after the adiponectin receptors. Science. 2013 Dec 20;342(6165):1460-1. doi: 10.1126/science.1249077. PubMed PMID: 24357309; PubMed Central PMCID: PMC4084614.   6: Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi  M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T,  Tanaka A, Yokoyama S, Kadowaki T. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. doi: 10.1038/nature12656. Epub 2013 Oct 30. PubMed PMID: 24172895.
CAS Num 924416-43-3
Chemical Formula C27H28N2O3
Molecular Weight 428.52
IUPAC Chemical Name 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Exact Mass 428.20999
Elemental Analysis C, 75.68; H, 6.59; N, 6.54; O, 11.20
Synonym AdipoRon;
Solubility Soluble in DMSO, not in water
Targets and Effects AMPK Agonist
Pathways Apoptosis
Appearance Solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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3-H Gill Street, Suite 300
Woburn, MA 01801
United State

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