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Anba Pharma Gemcitabine free base CAS No.: 95058-81-4 (free base) .. Product #: Anba-000966 Regular price: $90.00 $90.00

Gemcitabine free base

Catalog No.: Anba-000966
Weight: 500mg

Price: $90.00

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Gemcitabine is an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

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2: Maeda T, Tsuchiya M, Ishii J, Koda T, Kubota Y, Katagiri T, Tamura A, Otsuka Y, Shibuya K, Kaneko H. [A case of pancreatic cancer with distant metastasis successfully resected after neoadjuvant chemotherapy with a combination of S-1 and gemcitabine]. Gan To Kagaku Ryoho. 2014 Nov;41(12):2184-6. Review. Japanese. PubMed PMID: 25731464.
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4: Wei MY, Zhuang YF, Wang WM. Gemcitabine for the treatment of patients with osteosarcoma. Asian Pac J Cancer Prev. 2014;15(17):7159-62. Review. PubMed PMID: 25227807.
5: de Sousa Cavalcante L, Monteiro G. Gemcitabine: metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer. Eur J Pharmacol. 2014 Oct 15;741:8-16. doi: 10.1016/j.ejphar.2014.07.041. Epub 2014 Jul 30. Review. PubMed PMID: 25084222.
6: Nordh S, Ansari D, Andersson R. hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: a systematic review. World J Gastroenterol. 2014 Jul 14;20(26):8482-90. doi: 10.3748/wjg.v20.i26.8482. Review. PubMed PMID: 25024604; PubMed Central PMCID: PMC4093699.
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Chemical
CAS Num 95058-81-4 (free base)
Chemical Formula C9H11F2N3O4
Molecular Weight 263.2
IUPAC Chemical Name 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Exact Mass 263.07176
Elemental Analysis C, 41.07; H, 4.21; F, 14.44; N, 15.97; O, 24.31
Synonym LY-188011; LY 188011; LY188011; Abbreviations
Solubility Soluble in DMSO, not in water
SMILES Code O=C1N=C(N)C=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
Biological
Targets and Effects ribonucleotide reductase inhibitor
Pathways Apoptosis
Physical
Appearance Solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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Woburn, MA 01801
United State

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