FLLL32
FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor. FLLL32 specifically reduced STAT3 phosphorylation at Tyr705 (pSTAT3) and induced apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures. FLLL32 promoted loss of cell proliferation at lower concentrations than curcumin leading to caspase-3- dependent apoptosis. FLLL32 may have potential for targeting multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cells expressing constitutive STAT3 signaling.
1: Wu J, Patmore DM, Jousma E, Eaves DW, Breving K, Patel AV, Schwartz EB, Fuchs JR, Cripe TP, Stemmer-Rachamimov AO, Ratner N. EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene. 2013 Jan 14. doi: 10.1038/onc.2012.579. [Epub ahead of print] PubMed PMID: 23318430.
| Chemical | |
|---|---|
| CAS Num | 1226895-15-3 |
| Chemical Formula | C28H32O6 |
| Molecular Weight | 464.55 |
| IUPAC Chemical Name | (2E,2'E)-1,1'-(cyclohexane-1,1-diyl)bis(3-(3,4-dimethoxyphenyl)prop-2-en-1-one) |
| Exact Mass | 464.21989 |
| Elemental Analysis | C, 72.39; H, 6.94; O, 20.66 |
| Synonym | FLLL32; FLLL-32; FLLL 32 |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | O=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3 |
| Biological | |
| Targets and Effects | N/A |
| Pathways | Apoptosis |
| Physical | |
| Appearance | yellow solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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