CP 461
CP-461 is a member of a class of novel proapoptotic drugs that specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2. CP-461 inhibits the growth of a broad range of human tumor cell lines in vitro at micromolar concentrations and selectively induces apoptosis in cancer cell lines but not normal cells.
1: Sun W, Stevenson JP, Gallo JM, Redlinger M, Haller D, Algazy K, Giantonio B, Alila H, O'Dwyer PJ. Phase I and pharmacokinetic trial of the proapoptotic sulindac analog CP-461 in patients with advanced cancer. Clin Cancer Res. 2002 Oct;8(10):3100-4. PubMed PMID: 12374677.
| Chemical | |
|---|---|
| CAS Num | 227619-96-7 |
| Chemical Formula | C25H22ClFN2O |
| Molecular Weight | 420.91 |
| IUPAC Chemical Name | 1H-Indene-3-acetamide, 5-fluoro-2-methyl-N-(phenylmethyl)-1-(4-pyridinylmethylene)-, monohydrochloride, (1Z)- |
| Elemental Analysis | C, 71.34; H, 5.27; Cl, 8.42; F, 4.51; N, 6.66; O, 3.80 |
| Synonym | CP 461; CP-461; CP461; OSI 461; UNII-68OJX9I7DT. |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | Cl.CC1=C(CC(=O)NCc2ccccc2)c3cc(F)ccc3/C/1=C\c4ccncc4 |
| Biological | |
| Targets and Effects | N/A |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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