Cisplatin
Cisplatin is an inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.
| Chemical | |
|---|---|
| CAS Num | 15663-27-1 |
| Chemical Formula | Cl2H6N2Pt |
| Molecular Weight | 300.05 |
| IUPAC Chemical Name | (SP-4-2)-diamminedichloroplatinum; platinum, diaminedichloro-, cis- |
| Elemental Analysis | Cl, 23.63; H, 2.02; N, 9.34; Pt, 65.02 |
| Synonym | CACP; cisDDP; cisdiamminedichloro platinum (II); cisdiamminedichloroplatinum; Cisdichloroammine Platinum (II); Cismaplat; Cisplatina; cisplatinous diamine dichloride; cisplatinum; cisplatinum II; cisplatinum II diam |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | Cl[Pt]Cl.N.N |
| Biological | |
| Targets and Effects | N/A |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Yellow solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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