CHR-2845
CHR-2845 is a hydroxamic acid-derived histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CHR-2845 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in chromatin remodeling, inhibition of tumor oncogene transcription, inhibition of tumor cell division, and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins; this agent may specifically target HDACs in cells of the monocyte-macrophage lineage.
| Chemical | |
|---|---|
| CAS Num | 914605-76-8 |
| Chemical Formula | C28H43N3O5 |
| Molecular Weight | 501.67 |
| IUPAC Chemical Name | cyclopentyl (S)-2-cyclohexyl-2-((4-(8-(hydroxyamino)-8-oxooctanamido)benzyl)amino)acetate |
| Exact Mass | 501.32027 |
| Elemental Analysis | C, 65.07; H, 6.89; F, 4.48; N, 19.80; O, 3.77 |
| Synonym | CHR-2845; CHR2845; CHR 2845. |
| Solubility | soluble in DMSO, not soluble in water. |
| SMILES Code | O=C(OC1CCCC1)[C@@H](NCC2=CC=C(NC(CCCCCCC(NO)=O)=O)C=C2)C3CCCCC3 |
| Biological | |
| Targets and Effects | HDAC Inhibitor |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >5 years if stored properly |
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