Chidamide
Chidamide, also known as CS055 and HBI-8000 , is a n orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells.
1: Wong JC, Guo L, Peng Z, Zhang W, Zhang N, Lai W, Zhang Z, Zhang C, Zhang X, Song S, Pan D, Xie C, Li J, Ning Z, Lu X, He Y, Chen L. Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy. Bioorg Med Chem Lett. 2011 Jan 1;21(1):110-6. Epub 2010 Nov 19. PubMed PMID: 21145737.
| Chemical | |
|---|---|
| CAS Num | 743420-02-2 |
| Chemical Formula | C22H19FN4O2 |
| Molecular Weight | 390.41 |
| IUPAC Chemical Name | (E)-N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide |
| Exact Mass | 390.1492 |
| Elemental Analysis | C, 67.68; H, 4.91; F, 4.87; N, 14.35; O, 8.20 |
| Synonym | CS055; CS-055; CS 055; HBI8000; HBI 8000; HBI-8000; Chidamide. |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | O=C(NC1=CC(F)=CC=C1N)C2=CC=C(CNC(/C=C/C3=CC=CN=C3)=O)C=C2 |
| Biological | |
| Targets and Effects | PI3K Inhibitor |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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