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Anba Pharma Carmustine CAS No.: 154-93-8 .. Product #: Anba-004110 Regular price: $233.00 $233.00

Carmustine

Catalog No.: Anba-004110
Weight: 100mg

Price: $233.00

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Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily.

1: Pereira DY, Yip AT, Lee BS, Kamei DT. Modeling mass transfer from carmustine-loaded polymeric implants for malignant gliomas. J Lab Autom. 2014 Feb;19(1):19-34. doi: 10.1177/2211068213499157. Epub 2013 Aug 23. Review. PubMed PMID: 23975389.
2: Gutenberg A, Lumenta CB, Braunsdorf WE, Sabel M, Mehdorn HM, Westphal M, Giese A. The combination of carmustine wafers and temozolomide for the treatment of malignant gliomas. A comprehensive review of the rationale and clinical experience. J Neurooncol. 2013 Jun;113(2):163-74. doi: 10.1007/s11060-013-1110-x. Epub 2013 Mar 28. Review. PubMed PMID: 23535992.
3: Dixit S, Hingorani M, Achawal S, Scott I. The sequential use of carmustine wafers (Gliadel®) and post-operative radiotherapy with concomitant temozolomide followed by adjuvant temozolomide: a clinical review. Br J Neurosurg. 2011 Aug;25(4):459-69. doi: 10.3109/02688697.2010.550342. Epub 2011 Feb 23. Review. PubMed PMID: 21344976.
4: Nagaiah G, Almubarak M, Khan M, Altaha R. Cerebrospinal fluid leak during treatment with bevacizumab and irinotecan after carmustine-impregnated wafers placement in patients with grade 2 oligodendroglioma and glioblastoma multiforme: report of two cases and review of literature. Cancer Invest. 2010 Dec;28(10):1048-53. doi: 10.3109/07357907.2010.483499. Epub 2010 Sep 27. Review. PubMed PMID: 20873990.
5: Sabel M, Giese A. Safety profile of carmustine wafers in malignant glioma: a review of controlled trials and a decade of clinical experience. Curr Med Res Opin. 2008 Nov;24(11):3239-57. doi: 10.1185/03007990802508180 . Epub 2008 Oct 20. Review. PubMed PMID: 18940042.
6: Lin SH, Kleinberg LR. Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert Rev Anticancer Ther. 2008 Mar;8(3):343-59. doi: 10.1586/14737140.8.3.343. Review. PubMed PMID: 18366283.
7: Garside R, Pitt M, Anderson R, Rogers G, Dyer M, Mealing S, Somerville M, Price A, Stein K. The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation. Health Technol Assess. 2007 Nov;11(45):iii-iv, ix-221. Review. PubMed PMID: 17999840.
8: Zackheim HS. Topical carmustine (BCNU) in the treatment of mycosis fungoides. Dermatol Ther. 2003;16(4):299-302. Review. PubMed PMID: 14686972.
9: Fleming AB, Saltzman WM. Pharmacokinetics of the carmustine implant. Clin Pharmacokinet. 2002;41(6):403-19. Review. PubMed PMID: 12074689.
10: Weiss RB, Issell BF. The nitrosoureas: carmustine (BCNU) and lomustine (CCNU). Cancer Treat Rev. 1982 Dec;9(4):313-30. Review. PubMed PMID: 6762924.  
Chemical
CAS Num 154-93-8
Chemical Formula C5H9Cl2N3O2
Molecular Weight 214.05
IUPAC Chemical Name 1,3-bis(2-chloroethyl)-1-nitrosourea
Exact Mass 213.00718
Elemental Analysis C, 28.06; H, 4.24; Cl, 33.13; N, 19.63; O, 14.95
Synonym Synonyms
Solubility Soluble in DMSO, not in water
SMILES Code O=C(NCCCl)N(CCCl)N=O
Biological
Targets and Effects N/A
Pathways alkylating agent
Physical
Appearance Solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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