Apricoxib, also known as Benzenesulfonamide 42(4ethoxyphenyl)4methyl1Hpyrrol1yl, is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related metabolic pathways may represent crucial regulators of cellular proliferation and angiogenesis.
					 
											
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												| Chemical | 
											
										
										
																							
													| CAS Num | 
													197904-84-0 | 
												
																								
													| Chemical Formula | 
													C19H20N2O3S | 
												
																								
													| Molecular Weight | 
													356.44 | 
												
																								
													| IUPAC Chemical Name | 
													4-[2-(4-ethoxyphenyl)-4-methylpyrrol-1-yl]benzenesulfonamide | 
												
																								
													| Exact Mass | 
													356.11946 | 
												
																								
													| Elemental Analysis | 
													C, 64.02; H, 5.66; N, 7.86; O, 13.47; S, 9.00 | 
												
																								
													| Synonym | 
													CS701; CS-701; CS 701 CS-706; CS706; CS 706; TG01; TG-01; TG01; R109339; R-109339; R 109339;TP-1001; TP-2001 Benzenesulfonamide 42(4ethoxyphenyl)4methyl1Hpyrrol1yl | 
												
																								
													| Solubility | 
													Soluble in DMSO, not in water | 
												
																								
													| SMILES Code | 
													O=S(C1=CC=C(N2C(C3=CC=C(OCC)C=C3)=CC(C)=C2)C=C1)(N)=O | 
												
																						
																													
											
												| Biological | 
											
										
										
																							
													| Targets and Effects | 
													COX-2 inhibitor | 
												
																								
													| Pathways | 
													Apoptosis | 
												
																						
																													
											
												| Physical | 
											
										
										
																							
													| Appearance | 
													Solid powder | 
												
																								
													| Purity | 
													>98% (or refer to the Certificate of Analysis) | 
												
																								
													| Shipping Condition | 
													Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. | 
												
																								
													| Storage Condition | 
													Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). | 
												
																								
													| Shelf Life | 
													>5 years if stored properly |