AMRI-59
AMRI-59 is a potent inhibitor of PrxI. AMRI-59 increased cellular ROS, leading to the activation of both mitochondria- and apoptosis signal-regulated kinase-1-mediated signaling pathways, resulting in apoptosis of A549 human lung adenocarcinoma. Significant antitumor activity of AMRI-59 was observed in mouse tumor xenograft model implanted with A549 cells with no apparent acute toxicity.
1: Yang YJ, Baek JY, Goo J, Shin Y, Park JK, Jang JY, Wang SB, Jeong W, Lee HJ, Um HD, Lee SK, Choi Y, Rhee SG, Chang TS. Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I. Antioxid Redox Signal. 2016 Mar 10;24(8):453-69. doi: 10.1089/ars.2014.6187. PubMed PMID: 26528922.
| Chemical | |
|---|---|
| CAS Num | 923515-92-8 |
| Chemical Formula | C25H27N3O2 |
| Molecular Weight | 401.51 |
| IUPAC Chemical Name | 4-(4-(1H-pyrrol-1-yl)benzyl)-N-(3-acetylphenyl)piperidine-1-carboxamide |
| Exact Mass | 401.2103 |
| Elemental Analysis | C, 74.79; H, 6.78; N, 10.47; O, 7.97 |
| Synonym | AMRI-59; AMRI 59; AMRI59. |
| Solubility | Soluble in DMSO |
| SMILES Code | O=C(NC1=CC=CC(C(C)=O)=C1)N(CC2)CCC2CC3=CC=C(N4C=CC=C4)C=C3 |
| Biological | |
| Targets and Effects | peroxisome proliferator activated receptor (PPAR) |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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