AK301
AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release. This apoptotic response was significantly higher for AK301 than for other mitotic inhibitors tested (colchicine, vincristine, and BI 2536).
1: Chopra A, Bond MJ, Bleiler M, Yeagley M, Wright D, Giardina C. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PLoS One. 2016 Apr 20;11(4):e0153818. doi: 10.1371/journal.pone.0153818. PubMed PMID: 27097159; PubMed Central PMCID: PMC4838221.
2: Chopra A, Anderson A, Giardina C. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014 Jan 31;289(5):2978-91. doi: 10.1074/jbc.M113.499319. PubMed PMID: 24338023; PubMed Central PMCID: PMC3908429.
2: Chopra A, Anderson A, Giardina C. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014 Jan 31;289(5):2978-91. doi: 10.1074/jbc.M113.499319. PubMed PMID: 24338023; PubMed Central PMCID: PMC3908429.
| Chemical | |
|---|---|
| CAS Num | 314022-97-4 |
| Chemical Formula | C19H21ClN2O2 |
| Molecular Weight | 344.839 |
| IUPAC Chemical Name | (4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone |
| Exact Mass | 344.1292 |
| Elemental Analysis | C, 66.18; H, 6.14; Cl, 10.28; N, 8.12; O, 9.28 |
| Synonym | AK301; AK-301; AK 301. |
| Solubility | Soluble in DMSO |
| SMILES Code | ClC1=CC(N2CCN(C(C3=C(OCC)C=CC=C3)=O)CC2)=CC=C1 |
| Biological | |
| Targets and Effects | tubulin polymerization |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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