ABTL0812 sodium
ABTL0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR) (mTOR complex 1; mTORC1), rictor-mTOR (mTOR complex 2; mTORC2) and dihydrofolate reductase (DHFR) with potential antineoplastic activity. Upon oral administration, mTORC1/mTORC2/DHFR inhibitor ABTL0812 binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells.
| Chemical | |
|---|---|
| CAS Num | 57818-44-7 (free acid); |
| Chemical Formula | C18H31NaO3 |
| Molecular Weight | 318.4328 |
| IUPAC Chemical Name | sodium (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate |
| Elemental Analysis | C, 67.89; H, 9.81; Na, 7.22; O, 15.07 |
| Synonym | ABTL0812; ABTL-0812; ABTL 0812; sodium 2-hydroxylinoleate. |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | CCCCC/C=C\C/C=C\CCCCCCC(O)C([O-])=O.[Na+] |
| Biological | |
| Targets and Effects | mTOR inhibitor |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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