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Anba Pharma 4SC-207 CAS No.: 871015-11-1 .. Product #: Anba-002520


Catalog No.: Anba-002520
Weight: 10mg
Call for Price: 610-883-0668

4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. 4SC-207 may be a potential anti-cancer agent.

1: Bausch E, Kohlhof H, Hamm S, Krauss R, Baumgartner R, Sironi L. A novel microtubule inhibitor 4SC-207 with anti-proliferative activity in taxane-resistant cells. PLoS One. 2013 Nov 6;8(11):e79594. doi: 10.1371/journal.pone.0079594. eCollection 2013. PubMed PMID: 24324550; PubMed Central PMCID: PMC3855670.

CAS Num 871015-11-1
Chemical Formula C19H18N4O3S
Molecular Weight 382.43622
IUPAC Chemical Name (E)-ethyl 3-cyano-2-(3-(pyridin-3-yl)acrylamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate.
Exact Mass 382.10996
Elemental Analysis C, 59.67; H, 4.74; N, 14.65; O, 12.55; S, 8.38
Synonym 4SC207; 4SC-207; 4SC 207
Solubility Soluble in DMSO, not in water
Targets and Effects microtubule inhibitor
Pathways Apoptosis
Appearance white solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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Anba Pharma Company
3-H Gill Street, Suite 300
Woburn, MA 01801
United State

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Tel: 1+610-883-0668


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