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Anba Pharma GPX150 (CNDO1011) HCl salt CAS No.: 236095-29-7 .. Product #: Anba-001071

GPX150 (CNDO1011) HCl salt

Catalog No.: Anba-001071
Weight: 0
Call for Price: 610-883-0668

GPX-150, also known as CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

1. Zhang; Xini (Hoover, AL), Olson; Richard D. (Nampa, ID) 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them, United States Patent 5942605.
CAS Num 236095-29-7
Chemical Formula C27H33ClN2O9
Molecular Weight 565.02
IUPAC Chemical Name (8R,10S)-10-(((2S,4S,5R,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-7,8,9,10-tetrahydrotetracen-5(12H)-one hydrchloride
Elemental Analysis C, 57.40; H, 5.89; Cl, 6.27; N, 4.96; O, 25.48
Synonym CNDO1011; CNDO-1011; CNDO 1011; GPX150; GPX 150; GPX-150.
Solubility Soluble in DMSO, not soluble in water.
SMILES Code O=C1C2=C(O)C(C[C@](CCO)(O)C[C@@H]3O[C@@H]4C[C@H](N)[C@@H](O)[C@H](C)O4)=C3C(O)=C2C(C5=C1C=CC=C5OC)=N.[H]Cl
Targets and Effects topoisomerase II
Pathways Apoptosis
Appearance Solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >5 years if stored properly

Mailing Address

Anba Pharma Company
3-H Gill Street, Suite 300
Woburn, MA 01801
United State

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