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Anba Pharma HAC-Y6 CAS No.: 1331959-78-4 .. Product #: Anba-001329


Catalog No.: Anba-001329
Weight: 10mg
Call for Price: 610-883-0668

HAC-Y6 is a novel and potent microtubule inhitor. HAC-Y60 exhibited potent antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. Western blot and immunofluorescence experiments showed that HAC-Y6 depolymerized microtubules similarly to the effects of colchicine. HAC-Y6 exhibited its antitumor activity by disrupting microtubule assembly, causing cell cycle arrest and apoptosis through both extrinsic and intrinsic pathways in Hep3B cells. ( Oncol Rep. 2010 Nov;24(5)

1: Lin YC, Tsai JY, Yang JS, Lee YH, Hamel E, Lee KH, Kuo SC, Huang LJ. The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells. Int J Oncol. 2013 Nov;43(5):1596-606. doi: 10.3892/ijo.2013.2069. Epub 2013 Aug 21. PubMed PMID: 23970288.
2: Tsai JY, Hung CM, Bai ST, Huang CH, Chen WC, Chung JG, Kuo SC, Way TD, Huang LJ. Induction of apoptosis by HAC-Y6, a novel microtubule inhibitor, through activation of the death receptor 4 signaling pathway in human hepatocellular carcinoma cells. Oncol Rep. 2010 Nov;24(5):1169-78. PubMed PMID: 20878107
CAS Num 1331959-78-4
Chemical Formula C23H22N2O4
Molecular Weight 390.43
IUPAC Chemical Name 1-(9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indol-6-yl)ethanone
Exact Mass 390.15796
Elemental Analysis C, 70.75; H, 5.68; N, 7.17; O, 16.39
Synonym HACY6; HAC-Y6; HAC Y6.
Solubility Soluble in DMSO, not in water
Targets and Effects N/A
Pathways Apoptosis
Appearance white solid powder
Purity >98%
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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3-H Gill Street, Suite 300
Woburn, MA 01801
United State

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